Papaverine
Indications for papaverine
Papaverine is used to control coronary, peripheral, and cerebrovascular disorders.
Papaverine is also used as an antispasmodic for gastrointestinal disorders and cough.
It is used to diagnose and treat erectile dysfunction by injecting Cavernosum Corpus into the penis.
Mechanism of action of papaverine
Papaverine is one of the opium alkaloids, although it has no chemical or pharmacological similarities to other opium alkaloids. It has direct relaxing effects on smooth muscle, in part due to its ability to inhibit the enzyme phosphodiesterase.
Pharmacokinetics of papaverine
Papaverine is mainly metabolized in the liver and excreted in the urine.
۹۹% of the drug binds to plasma proteins.
Some of the drug is distributed into the systemic circulation after intracavernosal injection
Side effects of papaverine
Other complications (unknown percentage):
Cardiovascular: Cardiac arrhythmia (in rapid intravenous use), flushing, hypertension (mild),
central nervous system tachycardia: headache, lethargy, sedation, dizziness
: increased sweating, rash Gastrointestinal skin
: Abdominal pain, anorexia, constipation, diarrhea,
hepatic nausea: Cirrhosis of the liver
Hypersensitivity: Hypersensitivity reaction (liver)
Respiratory: Apnea (in rapid intravenous use)
Papaverine drug interactions
* General specifications of interactions:
No information has been reported.
Category X Interferences (Avoidance):
No significant interference has been identified.
Reduction of the effects of papaverine drugs:
Products containing levodopa
Reduction of the effects of papaverine by drugs:
No significant interaction has been identified.
Increased effects of drugs by papaverine:
Products containing levodopa
Increased effects of papaverine by drugs:
No significant interaction has been identified.
Interference with food:
Not mentioned.
